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It has been suggested that IGF-Eb may be more potent in promoting skeletal muscle hypertrophy.
However, ROS are particularly potent in promoting DNA damage and p53-dependent ROS detoxification is part of the cellular DNA damage response.
Asc-2-P was potent in promoting BMSC proliferation, in the absence of a mitogen, supporting significant increases in cell activity over 14 days of culture.
In agreement with this notion, Mine et al. reported that dermal equivalents containing papillary dermal fibroblasts were more potent in promoting epidermal morphogenesis than those containing reticular dermal fibroblasts (Mine et al., 2008).
Among the thiourea derivatives, our data show that a lead compound, designated as compound #326, 1-Naphthalen-1-yl-3-[5- 3-thioureido-phenoxy -pentyl]-thioureaa) appears to be the most potent in promoting Aβ phagocytosis and in inhibiting the LPS-induced expression of iNOS and COX-2 (when used at concentrations in the low μM range).
PP-DC isolated from GF mice were significantly less potent in promoting IgA production indicating that intestinal commensal bacteria can impact directly on DC function.
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Thus, it could be concluded that EPO and IGF1 possessed a potent synergism in promoting osteogenic differentiation, and the synergism was mainly attributed to co-regulation of different osteogenic regulators PPARγ and TAZ, which were targeted genes of EPO and IGF1 respectively.
OSM and IL-1 β have previously been described as a potent combination in promoting cartilage release in cartilage [ 7, 20].
We found no evidence that two of the most potent ASOs in promoting alternate splicing (ASOs 074 and 324) did not lower the overall expression of lamin proteins.
However, recent work has shown that BPA can be as potent as or more potent than estradiol in promoting some estrogenic activities (Alonso-Magdalena et al. 2006, 2012).
Taken together, we concluded that foxi3a is more potent than foxi3b in promoting IC differentiation in wild-type embryos, and that the timing of NaRC and HRC differentiation is strongly dependent on the relative concentrations of foxi3a and foxi3b accumulated in epidermal IC progenitors.
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