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We verified that the hydroalcoholic extract from the seed was most potent extract against MCF-7 cells.
The most potent extract of each sample with the lowest IC50 (in the MTT assay) was chosen for partial purification through column chromatography.
The most potent extract identified, the methanol extract from Fagara heitzii barks (FHB) were found to induce over 60% cell death in 4 out of 5 cell lines.
It is worth to mention that PapPE was the most potent extract that significantly decreases the AOM-mediated impairment of GSH/GSSG ratio.
The most potent extract identified from Ganoderma lucidum inhibited the growth of a gastric cancer cell line by interfering with cellular autophagy and cell cycle [ 75].
Potent extract of Psidium guajava and Juglans regia leaf extracts showed in vitro inhibitory effect on P. acnes and other organisms isolated from acne lesions of thirty-eight patients by disk diffusion method [ 52].
Similar(53)
This activity could be attributed to the hydroxyl radical scavenging by phytochemicals present in potent extracts.
The SI was calculated for the most potent extracts against K1 strain of P. falciparum with EC50 ≤1.00 μg/ml.
Nevertheless, the ethylacetate fraction for the three plants tested has been shown to be the most potent extracts.
To further investigate the potential mode of action of potent extracts, we examined Plasmodium morphology within 24 h of treatment.
Present study reports the antibacterial, antioxidant, and cytotoxic activities of P. hysterophorus plant parts in addition to characterization of potent extracts by LC MS analysis.
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