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"Maybe the most potent discoveries are reserved for last," Zuckerman declared.
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188 Hajduk and Greer analyzed the impact of fragment-based methods in drug design over the last decade, showing a list of all the targets studied through fragment-based approach that lead to potent inhibitors discovery.
Research for the book elicited in her a potent sense of discovery, and incredulity: "How wrong they had been, from Mrs Beeton down to my own contemporaries.
In order to discovery potent new mutant IDH1 inhibitors, we designed, synthesized and evaluated a series of allosteric mIDH1 inhibitors harboring the scaffold of 3-pyrazine-2-yl-oxazolidin-2-ones.
It is therefore imperative that the ongoing translational challenges are addressed, to convert scientific discoveries into potent antifibrotics and enable bridging of the translational gap between putative therapeutic targets and effective treatments for patients with chronic liver disease.
Rouvali combed through the pages of the First for new discoveries, something potent in the timpani or bird-like in the flute or overgenerous in the horns.
Harnessing Tg technology in the liver will help identify rational antifibrotic and proregenerative targets, facilitating efficient translation of scientific discoveries into potent therapies for patients.
Although there have been vast discoveries of potent cytotoxic agents attributed to Asian and Ayurvedic Indian traditional medicine, the need for this study is derived from the fact that much of the medicinal plants found in Africa are unexplored.
This structural information may support discovery of potent CK2 inhibitors.
Our efforts led to the discovery of potent CXCR3 antagonists with good pharmacokinetic properties.
In this Letter we describe the discovery of potent, selective, and orally active aminopurine JNK inhibitors.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com