It is a potent indication of the difficulties afflicting the $75 billion taxpayer-financed program created by the Obama administration in an effort to avoid foreclosure for as many as four million distressed homeowners.
Even after the Czechs ceded the presidency to Sweden at the end of June, Mr. Klaus remains a potent symbol of the difficulties of acting collectively in a union divided between leaders who favor greater integration, and those like Mr. Klaus who cling to national sovereignty.
Pregnancy can be a potent contributor to ventilation difficulty because of edema of the upper airway tract, and motion limitation of the thorax and diaphragm may occur unexpectedly [ 9– 11].
Even as he expressed what appeared to be obligatory optimism that the Democrats would take back the House, Mr. Gephardt dwelled in an interview on the difficulty of recruiting potent candidates and seasoned campaign managers, and on how Republicans and "special interests" were outspending Democrats this year.
Such devices might overcome the difficulties associated with designing potent synthetic receptors for proteins and hence, could open up new possibilities in medical diagnostics, pathogen detection, and proteomics.
Their progress to the clinic, however, has been slowed by difficulties in reproducing the potent immune responses seen in small animals to other models of vaccination.
Finally, the MGO quenching reactivity and the unselective (and unwanted) pyridoxal quenching are found to be influenced by the same parameters thus rationalizing the known difficulty in the design of potent and selective quenchers towards β-dicarbonyls.
Notwithstanding such difficulties, environmental epigenetics may become a potent concept to fully assess the impact of the exposome on human health [ 196].
Despite the great potential of ATR inhibitors, there is a paucity of potent, selective candidate pharmaceuticals due to of the difficulties in obtaining active ATR protein to support drug discovery efforts.
Antibacterial drug discovery projects often succeed in identifying potent molecules in biochemical assays but have been beset by difficulties in obtaining antibacterial activity.
