10, 11, 15 As already noted, lipid peroxidation is the most potent oxidative defect that damages β cells in T1DM.
Consistent with our in vitro observations, Epo-releasing scaffolds were found to be more potent in bridging the defect than BMP-2 loaded scaffolds, as determined by computed tomography (CT) scanning, fluorescent imaging and histological analyses.
A Rnd3-binding defective mutant of Syx1b mutated in the RBD (E164A/R165D) was more potent in rescuing the embryonic defects than wild-type Syx1b, showing that Rnd3 negatively regulates Syx activity in vivo.
The antiepileptic drug valproic acid (VPA) is a potent inducer of neural tube defects (NTDs) in human and mouse embryos.
Greatly increased levels of TORC1 were seen in mutant embryos, and treatment of mutant larvae with rapamycin, a potent TORC1 inhibitor, reversed the defects in cell size, indicating that the role of Tuberin in the TOR pathway is highly conserved in zebrafish.
However, it appeared to be less potent to rescue the extension defect induced by tMO1 at the dosage tested (Fig. 7F,G).
We conclude that our strategy leads to the discovery of new compounds that are among the most potent correctors of ΔF508-CFTR trafficking defect known to date.
When severe cartilage defects of the patella or potent pain due to patellofemoral arthritis existed, resurfacing of the patella was performed.
Furthermore, the authors demonstrated that feeding larvae expressing APP and BACE with a potent γ-secretase inhibitor (L-685,458) suppressed both the behavioral defects and the synaptic defects.
On the other hand, zTERT deficiency induced a defect in hematopoiesis through a potent and specific effect on the gene expression of key regulators in the absence of telomere dysfunction.
