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Based on the energy and conformation analyses, a potent core fragment is chosen to act as the starting point for new inhibitor design by means of LUDI and rational drug design approaches.
They're supposed to be rebuilding, but Joe Thornton, Patrick Marleau, Brent Burns, Joe Pavelski and Logan Couture remain a potent core.
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such a potent comedic force: a strong core cast who are – first and foremost – improvisers.
A great example of [the show's] fierce satire being offset by a potent emotional core".
The Lakers need a strong performance from Jeremy Lin to offset the Suns' potent guard core.
Having established the indazole as a potent heterocyclic core with good ligand efficiency, a number of SAR studies were carried out to explore chemical optimisation around this scaffold.
This holds true, in particular, with the potent lowering of core-fucosylation of the antigen-specific IgG.
The most striking finding in the current study is the highly variable but potent decrease in core-fucose levels observed for anti-D IgG1 antibodies in pregnancy, with 34 out of 70 samples showing a Fc-fucosylation of <50%, whereas fucose levels in total serum IgG are generally not reported to be lower than 90% (Wuhrer et al, 2009; Selman et al, 2012; Bakovic et al, 2013; Kapur et al, 2014b).
The pace of the drone strikes appears to have left the cadre of Qaeda operatives in Pakistan reeling, and American intelligence officials now believe that Al Qaeda's affiliate in Yemen is a more potent threat than the "core" group of operatives hiding in Pakistan.
Spiro-imide derivative 8c containing a 6-methylthieno[2,3-b]pyridine core exhibited potent ACC inhibitory activity and favorable pharmacokinetic profiles in rats.
The results of 3D-QSAR models indicates that inhibition potency of steroidal AIs is markedly dependent on the hydrophobic nature of steroid core and potent steroidal AIs form hydrogen bonds with residues and interact with the heme iron.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com