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In "Passage for Two," Ms. Laracey and Mr. Finlay meet as if by chance; touch and feel each other with increasingly potent contact and friction; and then go their separate ways without so much as a backward glance.
To date, cellular response assays have been employed mainly in experimental settings to characterize responses to a limited number of known, potent contact sensitizers, but not respiratory sensitizers.
Hydroperoxides formed via the oxidation of terpenes and terpenoids can be potent contact allergens (Gafvert et al. 1994; Karlberg and DoomsGoossens 1997; Matura et al. 2003, 2005; Skold et al. 2002).
Moreover, some researchers have noted that dendritic cell responses were relatively "modest," were "not sufficiently resilient to identify allergens," and demonstrated considerable "donor-to-donor response variations" even when testing potent contact sensitizers (Ryan et al., 2009; Toebak et al., 2009).
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Molecular docking studies indicated that upon Bergman cyclization furin-Eda-peptide provided a more potent interaction and better contact with the P-domain of furin protein characterized by the segment 548Val-Leu-Glu-Ile-Glu-Asn-Thr-Ser-Glu-Ala557 which is located not too distant from the catalytic domain [61].
It seems the combination of common interests and frequent contact is a potent formula for forming and nurturing relationships among science trainees.
They infiltrate and displace normal brain tissue and therefore must have invoked a potent mechanism to overcome classical contact inhibition.
Overall, the data indicated that systemic and topical applications of VFB to RHE resulted in a common modulation of genes, with the systemic contact being more potent than the topical route.
As exposure of sewage workers implies contact with multiple potent genotoxics at varying levels (by concentration, time and location) and routes of exposure (by inhalation, dermal and ingestion) [ 9], characterizing and quantifying it are extremely difficult, and trying to relate adverse outcomes to single toxicant is inappropriate.
Within the context of rhesus macaque social structure, this makes adaptive sense: high ranking male macaques are potent social threats, and direct eye contact is a social challenge that is likely to invite retaliation [28], [29].
For example, Corsini et al. (Corsini et al., 2009) incubated human keratinocytes with one of three respiratory sensitizers, nine contact sensitizers, or four potent irritants.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com