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Functional enrichment of chromatin communities could be a potent constraint that ties together transcription-associated chromatin in the nucleus.
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And desire-based reasons theorists do not, like Korsgaard and Smith, interpret any idealizing constraint as so potent as to free all our reasons from any counterfactual dependence on the specifics of what we desire.
If the idealizing constraint is made potent enough, there might, as neo-Kantian rationalists believe, be motivations to which there is a sound deliberative route from any starting point (Korsgaard 1986; Smith 1994, 1995).
In resource-limited settings, in which financial and structural constraints limit access to new drugs, it is often difficult to access potent new cART regimens for children with virologic failure on first-line therapy.
Within the time constraints of an outbreak occurring within a small susceptible pool, treatment may be more potent at inducing resistance than prophylaxis [4] [10], depending on the relative fitness and seeding rate assigned to emergent drug-resistant viruses [6].
Conformational constraint has been used as the key design element in the identification of a series of potent and selective ETA antagonists.
Although the conformational constraint did not protect the compounds from metabolism by N-dealkylation, several bicyclic analogs were found to be more potent than the unconstrained lead compound.
Novel potent peptidomimetic inhibitors, containing 3-galloylamido-N′-substituted-2,6-piperidinedione-N-acetamide, have been designed and synthesized according to the conformational constraint strategy.
No constraint.
Some constraint.
Potent stuff!
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