Sentence examples for potent attenuation from inspiring English sources

Ligand-bound GR is able to antagonize the activity of immunogenic transcription factors such as nuclear factor-κB (NF-κB 3, AP-14,5, aNF-κB 3t6, resulting in a potent attenuation of inflandation.

Notably, there was potent attenuation of IFNα, IFNγ, and IL-6 signaling across multiple immune cell subsets that was correlated to periods of increased SLE disease activity, suggesting that previously unrecognized, negative feedback loops oppose critical cytokine activities.

Synergistic activation or inhibition of these microRNAs, which will be investigated in future studies, may collectively permit the potent attenuation or activation of fibrosis for therapeutic applications.

Further studies have shown that HIF inhibitors are more potent in attenuation of HIF-dependent transcriptional activity under hypoxia than under normoxia [ 30, 31].

However, since rat UCMSCs were extremely potent in cell growth attenuation in simple in vitro cell culture studies where no immune cells or immunoglobulin were involved, it is likely that their in vivo effect is also independent of nonspecific immune surveillance induced by xenotransplantation.

Finally, although not replicated in the Swedish cohort, we found attenuation of the potent tumour-suppressor phosphatase and tensin homologue, PTEN, in TMPRSS2 ERG fusion-positive tumours.

Its attenuation is due to potent stimulation of the innate immune system by the virus.

Physical activity can serve as potent prescription in the delay and attenuation of the CVD complications for persons with type 2 diabetes but additional comparative studies are needed regarding the cardiac response to exercise under diabetic conditions at various time points of the disease.

Interestingly, they possess potent anti-inflammatory activity and drug-induced attenuation of microtubule dynamics might provide a possible mechanism contributing to dissipating cytosolic signaling thus dampening inflammatory responses.

Knockout animal studies demonstrated IL-10 was a potent anti-inflammatory mediator, resulting in the attenuation of lung neutrophil infiltration and injury after visceral ischemia [ 140].

The PE38KDELKQK-based immunotoxin has been proved to retain potent anti-tumor activity but with a remarkable attenuation in VLS.