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Isothiazolo[4,3-b]pyridines are known to be endowed with potent affinity for cyclin G associated kinase (GAK).
CGRP receptor antagonists containing these moieties displayed potent affinity, functional antagonism and excellent oxidative stability.
Brutschy, M., Schneider, M. W., Mastalerz, M. & Waldvogel, S. R. Porous organic cage compounds as highly potent affinity materials for sensing by quartz crystal microbalances.
Now he has "a reputation for tranquillity" to protect and will not be hitting out at anyone, yet still he feels a potent affinity with the wildwood.
It was found that the 2R,3R-pyrrolidine isomer possessed the most potent affinity among the four stereoisomers.
The optimization of these compounds led to compound 48 with potent affinity for TSPO and good in vitro PK profile.
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1-Hydroxymethyl groups of the tricyclic heteroarmatic compounds displayed the potent affinities toward A1AR.
Several compounds exhibit potent affinities for both the NK1 receptor (<10 nM) and for the NK2 receptor (<50 nM).
Third, the purified recombinant Ulp1(3)(C580S) protein is a potent affinity-tag for the purification of Smt3 conjugates and SUMO-modified proteins.
All known antipsychotic drugs have potent affinities for the DRD2 receptor.
Risedronate is an oral, nitrogen-containing bisphosphonate that possesses properties that provide easier dosing alternatives for patients, such as strong affinity for bone, potent antiresorptive action, high concentration and persistence in bone tissue, and excellent tolerability.
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