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The cell-surface bound molecule serves as a potent adhesion molecule while the secreted form has chemotactic activity.
Whereas recent work showed that potent adhesion blocking antibodies were generated in rats immunized with full-length FCR3-VAR2CSA recombinant protein [37], in this study, only rabbits and not mice developed inhibitory antibodies to a full-length 3D7-VAR2CSA protein.
Furthermore, the full-length recombinant protein had a much more compact structure than predicted from individual domains [38] and a DBL1-6 recombinant protein from the FCR3-CSA allele induced potent adhesion blocking antibody responses against the homologous CSA-binding parasite line that were almost 100-fold higher titer than the FCR3-DBL4 recombinant protein [37].
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The soluble form of the CX3CL1 protein is a potent chemoattractant of T-cells and monocytes, while the cell-surface-bound form promotes strong adhesion of those leukocytes [ 121].
We propose that PAPC functions as a molecular "governor" to limit the activity of the more potent cell adhesion inhibitor, FLRT3, and together they decrease cadherin-mediated cell adhesion in an optimal range for morphogenesis.
In an effort to develop potent cell adhesion molecule inhibitors, a series of chromone derivatives bearing alkoxycarbonylvinyl unit at the C-3 position, that is, the chromones 8a d and 9a d, were designed and synthesized, and evaluated for their ICAM-1 inhibitory activity on human endothelial cells as well as their effect on NADPH-catalyzed rat microsomal lipid peroxidation.
The results accounted for the action of LNG in EC in those women who take LNG before the LH surge, based on the potent gamete adhesion inhibitory activity of glycodelin-A.
In order to develop potent and selective focal adhesion kinase (FAK) inhibitors, synthetic studies on pyrazolo[4,3-c][2,1]benzothiazines pyrazolo[4,3-c][2,1]benzothiazinestargetedcarried out.
This combination was seen to be more potent in achieving better adhesion than individual components alone.
Cytokines in recombinant or purified forms are potent inducers of EC adhesion molecule expression in vitro.
Through the potent inhibition of these adhesion molecules and inflammatory mediators, Baicalin might further impede the recruitment of TH1, TH2 or other effector cells in vivo.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com