Sentence examples for potent activation of from inspiring English sources
Furthermore, inhibition of protein phosphatase 2A (PP2A), which normally prevents the basal activity of mitogen receptors from activating downstream signaling cascades (Wang et al., 2003; Van Kanegan et al., 2005), was unable to activate ERK despite potent activation of Akt in cells depleted for cavin-3.
By combining genome-wide analysis and proteomic analysis, we showed that the main consequence of the stimulation of MSCs by melanoma-activated TIL is the potent activation of the IFN signalling, resulting in the production of several interferon-inducible pro-inflammatory TH1 cytokines and chemokines, including IL-8, CCR5, and CXCR3 ligands (CCL5 and CXCL9-11, respectively).
Then EspFu activates N-WASP, allowing a potent activation of actin polymerization mediated by N-WASP/Arp2/3 [ 86].
The stimulation of osteoclasts with RANKL leads to potent activation of NFATc1 (Nuclear factor of activated T cells, cytoplasmic 1), as demonstrated by gene expression profiling [ 105].
Protein threonine phosphatase inhibition by CLA provided potent activation of Nrf2 being the first sub-nanomolar activator of the Nrf2 system.
The erbB2/erbB3 complex is believed to be the most biologically active erbB heterodimer [ 43, 44], with potent activation of the downstream signaling cascade [ 13, 14].
Specifically, TNF-α is a potent activator for activation of NADPH oxidase, resulting in the formation of ROS [35].
Therefore, the addition of potent activation domains to wild-type transcription factors is a generalizable approach for increasing transcriptional activity.
In this study, we evaluated the effects of fusing potent activation domains to the transcription factor MyoD, the master regulator of the skeletal myoblast lineage.
Exposure of cells to BIO plus methotrexate resulted in potent synergistic activation of BAR activity, reduction of β-catenin phosphorylation at GSK3-specific sites, and accumulation of nuclear β-catenin.
This triple combination also showed a potent synergistic activation of several key TSGs as determined by real-time PCR.
