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Exact(32)
The Leu2 was semicritical, where a six-fold loss in potency was observed.
Upon di-substitution at phenyl ring, good enhancement in the potency was observed (compounds 5m, 5n and 5o).
When the anti-HIV antibody b12 was tested as an IgA, IgM or IgG, equivalent neutralization potency was observed [14].
In contrast, a 100-fold decrease in molar potency was observed at bradykinin receptors in intestinal and uterine smooth muscle preparations.
Several compounds were observed to be cytotoxic at sub-micromolar level and a pattern of increased aerobic potency was observed in cells over expressing POR.
Enhancement of DNA cleavage potency was observed with those compounds which could interact with DNA through intercalation of the extended aromatic ring or through electrostatic attraction with electron poor aromatic ring.
Similar(28)
When the cells were plated onto plastic, they did not form spheres, but aggregated to form 3D acinar-like spheroids when cultured on Matrigel, PCL, and PCL microwells, with the greatest aggregating potency being observed on the PCL microwells.
The best improvements in neutralizing potency were observed for the RSV neutralizing VHH, RSV-D3.
Truncating KNK10 from either C- or N-terminus results in a decrease in both bactericidal potency and salt resistance, although very short peptides are reached in both series (KNK5-WWW, KNK4-WWWWW, and KNG5-WWW, respectively) before significant reduction in bactericidal potency is observed at low ionic strength.
Similar differences in potency were observed in the BG1Luc4E2 cell line.
To validate whether ScKrs1 positions 324 and 340 are significant factors in cladosporin selectivity and specificity, these positions were mutated in yeast to mimic those residues found in Plasmodium spp. Substantial increases in cladosporin potency were observed for both mutations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com