Using public bioactivity data, we have used MMPs as a consistent reference framework to identify sets of chemical replacements that either have the propensity to induce large-magnitude potency changes or tend to retain compound potency across diverse targets [3, 4].
Rather than discarding expired lots, the C.D.C. plans to store them indefinitely since the vaccine seems to retain its potency almost indefinitely.
Decry "Wicked" as a bloated, preachy muddle if you will (and yes, I did), but money talks as loudly in theater as it does in other spheres of American life, and if the Broadway musical is to retain any potency as a cultural force, it needs this kind of powerhouse show.
Such adaptations appear to be critical for the ability of the diarylpyrimidine NNRTIs to retain their potency against a wide range of drug-resistant HIV-1 RTs.
The vaccine needs to be kept cool to retain its potency so the vaccine carriers were filled with icepacks.
Many current vaccines must be maintained within specific temperature ranges to retain their potency, and therefore, the associated expense of maintaining the "cold chain" is estimated to cost vaccine programs $200 300 million annually globally.
Thimerosal also causes loss of antigenicity of IPV, and therefore IPV may need to be presented in a separate vial from thimerosal-containing wP to retain its potency over time.
To retain optimal potency, vitamins and other dietary supplements should be stored in a cool and dry place.
To retain the greatest spiritual potency, Buddha icons in Thai temples had to resemble as closely as possible an original prototype that tradition erroneously believed had been made during the lifetime of the Buddha.
Here we assessed the ability of the rice cysteine protease inhibitor, oryzacystatin I (OCI), to retain its protease inhibitory potency when used as a template to devise hybrid inhibitors with dual activity against papain-like proteases and carboxypeptidase A (CPA).
