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Potency studies exhibited a PD50 of about 107 pfu/animal while a dose of 4×107pfu/animal fully protected swine against FMDV intradermal challenge.
Potency studies in mice conducted every 6 months confirmed that all lots were stable and potent throughout the trial.
However, this is unlikely, as biannual potency studies of the lots of vaccine used in this trial demonstrated continued ability to induce antigen-specific antibodies in animals.
Both stored Pfs25/ISA 51 and Pvs25/ISA 51 vaccines met specified criteria in routine stability and potency studies (Table 1).
Encouraging first clinical results confirm those observed in in vitro anti-tumour potency studies.
Another issue to be taken into consideration for all siRNA potency studies is the concentration of siRNA used in the silencing experiment.
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"The last potency study in 2008 showed that skunk was 80% of the market so about 80% of these kids were probably smoking skunk.
"We used NIDA marijuana from one of the medical marijuana patients receiving NIDA marijuana on a compassionate basis who sent her marijuana to a DEA-licensed lab conducting our medical marijuana potency study that tested higher potency marijuana from medical marijuana dispensaries," MAPS founder and president told me.
The sampling frame for this uterotonic drug accessibility and potency study includes all private pharmacies surrounding those 64 public health facilities, as pharmacies tend to cluster around health facilities in India.
More importantly, it allows us to build a quantitative framework for studying the length of the gene silencing period and number of siRNA molecules (of both types) required for the same for a cost-potency study.
Molecular modeling also provides a rational basis for modification of our three lead compounds to identify related ones with greater potency; these studies are underway.
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