In potency scaling experiments, two consensus policies are compared.
Fig. 8 Effect of applying potency scaling (knowledgeable policy) or not (realist policy) to build the consensus.
This potency scaling technique allows to bias the search space towards the detection of increasingly potent hits [10].
The effect of potency scaling is that it brings highly active molecules closer to the query but pushes further away less potent molecules (Fig. 8).
The authors observed that using multiple reference compounds and potency scaling allows to direct the search towards detection of more potent database hits.
In our experiments (Table 4) and in terms of bringing the most active molecules closer to the query, there is a clear advantage of the knowledgeable policy (which is potency scaled) versus the realist one.
In a 1996 publication, Paul Stamets defined a "potency rating scale" based on the total content of psychoactive compounds (including psilocybin, psilocin, and baeocystin) in 12 species of Psilocybe mushrooms.
Absent a potency-weighted scaling that accounts for androgen antagonism, PPAR activation, and other pathways by which phthalates might affect body mass, we chose to use unweighted, aggregate molar concentrations and present alternative weighting of concentrations as a sensitivity analysis.
All of these have demonstrated the successful control of pure WZ NWs grown on non-crystalline substrates, which present the potency of large-scale preparation for various high performance technological applications.
To examine whether our DNA vaccine had sufficient potency to be scaled from mouse to human, we examined the delivery of our DNA vaccine using the Inovio Elgen100 device for the first time in the clinic.
SAFC Pharma, a member of the Sigma-Aldrich Group, is to undertake a US$30 million expansion of its Madison, Wisconsin facility, designed to significantly increase its capacity to produce commercial scale high potency active pharmaceutical ingredients (HPAPIs).
