Sentence examples for potency reductions from inspiring English sources
For example, 12- and 50-fold in vitro potency reductions were observed, respectively, for human growth hormone and glucagon-like peptide 2 which had been fused with XTEN.
It binds with high affinity to renal AT1Rs (K D of 49.4 nM) and has antagonistic efficacy with fourfold less potency reduction of blood pressure (ED50 of 25.5 mg/kg) relative to losartan.
Accumulating evidence shows that the phenotypic features of the DS brain can be traced back to the fetal period since the DS brain exhibits proliferation potency reduction starting from the critical time window of fetal neurogenesis.
Vigorous research is focussing on refining AO chemistries and modifications to improve bioavailability, safety, potency and reduction of off-target effects [5 7].
Both the potencies showed reductions in frequencies of sperm with abnormal head shapes in all the fixation intervals and the differences were statistically significant in almost all the fixation intervals except for 6 hr.
The decreased neutralizing potency and reduction in affinity of scFvs as compared to full-length MAbs can be explained by monovalent binding properties, as purified anti-VLY scFvs were found predominantly in a monomeric form.
Given this potency, an 18percentt reduction in methane emissions from cattle isn't going to be anywhere near enough to turn dairying or beef production into sustainable industries.
This value leaves some room for improvement, and the sense conjugate duplex (7+ 10) showed enhanced potency (83% mRNA reduction).
Whether this difference in potency is relevant to reductions in DM events during adjuvant therapy remains unclear.
Substitutions at positions 1, 4, 8 and 9 resulted in approximately 10-fold reductions in potency at both responses.
Substitution of alanine by cysteine at position 1 caused around a 10-fold decrease in potency on cAMP and modest reduction in Emax; these changes were accompanied by a sixfold decrease in affinity.
