Pao zhi is a common traditional approach that usually occurs before most herbs are prescribed whereby during processing, secondary plant metabolites are transformed, thus helping to increase potency, reduce toxicity and altering their effects.
According to the theories of TCM, the main purposes of herb processing are to increase potency, reduce toxicity, and alter the effectiveness of the raw materials.
Introduction of the spirocyclic pyranochromene scaffold yielded several advantages over previous generation cores, including increased potency, reduced efflux, and reduced CYP2D6 inhibition.
It is increasingly clear, however, that inhaled biological therapeutics can offer some strong advantages over traditional therapeutics including increased potency, reduced systemic availability, and potentially, a longer duration of action.
Such concerns have diminished in recent years as newer medicines have become available with fewer toxicities and better potency (reducing the chance of resistance development).
By synthesizing hundreds of Hh-Ag1.1 derivatives, several related compounds (Hh-Ag 1.2, 1.3, 1.4 and 1.5) were identified with enhanced potency, reduced toxicity and/or improved stability.
These limitations of dynasore lead to the synthesis of dihydroxyl and trihydroxyl dynasore analogs, called the Dyngo compounds, which have improved potency, reduced cytotoxicity, and reduced detergent binding [ 26].
Moreover, the titre values measured by different laboratories were transformed into international units because the use of relative potency reduces the variation between laboratories, in contrast to direct titre estimation [ 15].
During processing, secondary plant metabolites are transformed, thus helping to increase potency and reduce toxicity, and altering their effects [4].
While many current drugs provide effective therapies, more precise delivery to target sites can increase net potency and reduce toxicity.
The other was the replacement of the phenyl ring with a pyridine ring to improve in vivo potency and reduce hERG affinity.
