Sentence examples for potency range of from inspiring English sources

Optimisation of these three components generated a series of inhibitors with a potency range of 100 200 nM.

However, due to its high sensitivity, the assay could be used to analyze the potency range of a specific drug, at least as defined by the relative fluorescence intensity and percentage of fluorescent cells.

These plots illustrate the wide potency range of the individual chemicals, from 10too 900 mg/kg, and the dose-related decrease in activity for all 11 chemicals.

The neutralizing potency range (0.6 3.7 µg/ml) of CR6261 is similar to previously reported H5N1 neutralizing monoclonals (0.07 7 µg/ml) isolated from immortalized B cells of H5N1 survivors [14].

The inhibitor M has been shown to mimic the tricyclic neuroleptic class of inhibitor, where replacement of the diphenylmethane with a 10,11-dihydro-5 H-dibenzo[ a,d]cycloheptene ring system caused a fivefold decrease in IC50 value of the inhibitor, placing it in the same potency range as the tricyclic class of inhibitors.

Notably, potencies of <0.002 μ m were at the limit of the enzyme assay′s sensitivity; compounds at this end of the potency range are probably sub-nanomolar inhibitors.

(q_i) is assigned a weight (w_i) given it's IC50 value (IC50qi) and the IC50 value of the least active molecule (IC50min): begin{aligned} w_i = log(mathrm {IC50_{min}}) - log(mathrm {IC50}_{q_i}) + 1.0 end{aligned} (1)This logarithmic weighting scheme ensures linear scaling over the entire potency range and attributes a weight of one to the least active molecule [10].

While the IMiDs share many of thalidomide's biological properties, the relative potency and range of these effects vary quite dramatically from each other and from thalidomide.

Although visualization of key fragments in X-ray-derived structures is still required to develop fragments into small molecules with good potency, a range of additional biophysical techniques to screen for fragment hits, such as surface plasmon resonance (SPR), isothermal titration calorimetry and thermal shift, has made the area generally more accessible.

Combined with the destructive capacity that can be wielded by small non-state groups because of the potency of a range of potential weapons, armed conflict is harder to label in distinct categories than it used to be.

A subset of 60 (K i) and 322 (IC 50) SAR transfer series displayed strictly corresponding (regular) potency progression (often over different potency ranges).