Sentence examples for potency parameters from inspiring English sources

The efficacy and potency parameters obtained for the four modelled pharmacodynamic endpoints are presented in Table  3.

We used C50 values from in vitro experimental data sets [ 25, 26] and calibrated other potency parameters to match per granuloma outcomes in INH and RIF treated NHPs [ 20, 30].

Aurora A is suggested to be one of the proliferation potency parameters which is an independent prognostic factor for early invasive breast cancer patients, and OPG long term exposure drastically induced the copy number of Aurora A kinase (Fig.  10c) further supporting our results in Fig.  8.

For example, a translational PK-PD model was developed to describe the time-course of the drug-induced thrombocytopenia by separating system-specific (platelet baseline level, maturation time, rate of progenitor production, feedback regulation) and drug-specific (e.g., drug potency) parameters.

The final model was simplified to include a common drug potency parameter (the daily sunitinib AUC resulting in half of the maximum drug effect, IC50) for all the four biomarkers that were found to be highly correlated for VEGF, sVEGFR-2, and sVEGFR-3 (75 92%).

Administered of seed extract of M. pruriens to diabetic rats showed significant improvement in sexual behavior, libido and potency, sperm parameters, DSP, and hormonal levels as compared to diabetic rat without extract treatment [ 89].

Interestingly, significant non-zero values of W W are obtained even in the absence of any mutually catalytic effect, i.e. when both enantiodiscrimination and catalytic-potency-related parameter are low (σ ε and σ, respectively. See Eqs. 6 and 3).

Pharmacological studies revealed high hCA IX inhibitory potency in the parameters nanomolar range.

The main pharmacodynamic parameters (potency, efficacy, and sensitivity) were estimated for four endpoints (body temperature, creeping speed, ground vertical reaction force and clinical lameness score).

Optimization for several parameters including potency in the presence of human plasma, selectivity against CYP3A4 inhibition and improved rat oral bioavailability led to the identification of 8d which demonstrated antihypertensive efficacy in a transgenic rat model of human hypertension.

Here we present an analysis of parameters influencing potency of peptide phosphonate ABPs for trypsin-fold S1A proteases, an abundant and important class of enzymes with similar substrate specificities.