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What matters is their potency over others.
Vitamins lose their potency over time and must be stored at, or below, room temperature.
But if the vaccine should begin to lose potency over time, that could easily be remedied by a booster shot.
The disturbing, violent, neo-Bressonian work of the French film-maker Bruno Dumont has waxed and waned in potency over the years: his Life of Jesus (1997) and the bizarrely compelling Humanity (1999) established his vision.
There has been some talk this week, sparked by the passing of Lady Thatcher, of how the unions of the 60s have lost much of their potency over the past three or four decades.
These inhibitors show improved enzymatic potency over their open-chain analogue.
However, these approaches suffer from rapid clearance and reduced potency over time.
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In a recent conversation, Gillian Shepherd, a Manhattan allergy specialist, addressed the same point, noting that antihistamines like Claritin and Allegra are about equal in potency to over-the-counter drugs like Chlor-Trimeton.
Herein, we present the design and synthesis of 2(1H -pyrazinone based HCV NS3 protease inhibitors and show that elongated R3 urea substituents were associated with increased inhibitory potencies over several NS3 protein variants.
The compounds containing a triazole linker with different groups at the 1-position (8 – 12 ) have a range of potencies over three orders of magnitude.
Recent developments of peptides related to T-20 have resulted in new drugs with improved potencies over T-20, and these can also be incorporated into XTEN.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com