Sentence examples for potency on both from inspiring English sources

The exploration led to development of potent drug-like, non-metabolite tool compounds with nanomolar potency on both the human and murine receptor orthologues and excellent physicochemical and in vitro stability properties.

The cell proliferation assay in vitro demonstrated that most target compounds had inhibition potency on both c-Met and VEGFR-2, especially compound 9h, 12b and 12d.

Lipophilicity of this compound is in the low end of the desired range but it is interesting to note that the compound exhibited a ligand lipophilicity efficiency (LLE) >5 based on ClogP and almost sustained potency on both mSUCNR1 and hSUCNR1.

The first potent inhibitor of a protein methyltransferase is BIX-01294 which was published in 2007 exhibited low microM potency on both G9a (EHMT2) and GLP (EHMT1), and showed some cellular toxicity at higher doses [ 83].

Overall, from our findings, we conclude that, despite its reduced agonist potency on CXCR4, both the prolonged immobilization and increased stability of γ-wt would determine the superior capacity of this isoform to promote chemotaxis in vivo as compared to α-wt.

This only affected the potency marginally on both receptor orthologues, but exposes a potential metabolically labile site.

Compound 10d, which exhibits approximate potency on CDK4/6 (IC50 = 7.4/0.9 nM), has both good pharmacokinetic characters and high selectivity on CDK1 compared with LY2835219.

Furthermore, both drugs have demonstrated potency on anthracycline-resistant tumours (Lau et al, 1998, Ray-Coquard et al, 1998).

Inhibitory effect curves are presented in Fig. 2b and c. Results showed that both suramin and BPs have anti-complement potency on the LP with a determined IC50 value of 0.368±0.071 mg/mL and 1.057±0.003 mg/mL respectively.

Interestingly, both dextromethorphan and its metabolite dextrorphan 24 showed enhanced potency on N615K-containing NMDARs in comparison to wild-type NMDARs (twofold and 5.6-fold, respectively; Table 2).

Finally, both methods were integrated to predict the protein targets and the potency on plasmodial DHFR for the GSK TCAMS dataset, which comprises 13,533 compounds displaying strong anti-malarial activity.