Since the rates of adduct formation with protein sulfhydryl groups are linked to toxic potency, applications of this type illustrate the potential for additive toxicity by type-2 alkenes and suggest that the different subclasses of α,β-unsaturated carbonyl compounds can interact additively.
NP-mediated delivery of cell-bound toxin into the cytosol enhanced the potency of the type I plant toxin gelonin by more than 50-fold.
As expected, genes associated with the anti-viral PKR, 2-5A synthetand and Mx pathways were more highly induced by type I IFNs, correlating with the greater antiviral potency of type I compared to type II IFNs [5].
Previous studies revealed a critical role for both the miltefosine transporter LdMT and the LdRos3 protein in the uptake and potency of alkylphosphocholine type drugs and in phospholipid translocation at the plasma membrane of Leishmania parasites [11], [12], [14].
The increased potency of potent type A inhibitors for the proton-pumping activity of NADH Q reductase (Table 2 ), similarly to the action of amiloride-like inhibitors of the antiporter activity of the complex.
Therefore, by limiting the proliferative capacity of naïve CD4+ T cells and inhibiting the expression of a key Th2 transcription factor, IL-27 appears to regulate the potency of nascent type II inflammatory responses.
In C. elegans, caloric deprivation such as transient starvation for 3 to 18 hr during early adulthood can reduce excitability in the spicule intromission circuitry and prolong the mating potency of wild type (LeBoeuf et al., 2011).
This simplicity of type II venom might explain the general prevalence of type I venoms in rattlesnakes [ 29], despite the apparent advantage in potency of type II venoms.
Interestingly, the rank order of potency of DMPP is also one of the main differences between recombinant and native receptors of this type.
Interestingly, the developmental potency of a cell type, i.e. germ cells>ES cells>partially differentiated cells > terminally differentiated cells, seems to inversely correlate with the global 3'UTR length.
