Exact(5)
The pEC50 was obtained for the purpose of comparing the potency of the different substances, calculated using GraphPad Prism software (GraphPad Software, San Diego, California, USA).
However, a reliable conclusion about the potency of the different DC populations should be based on in vivo experiments.
The variability in TTD and potency of the different LF proteins tested in this study can easily explain the high degree of variability seen in the dosages required by different laboratories for LT lethality in various animal models.
In vitro systems should be applied for further identification of the mechanism of the carcinogenic effects, and animal experiments are urgent for comparison of the carcinogenic potency of the different hexavalent salts.
Furthermore, conclusions on the relative potency of the different ENMs for both toxicity and bioactivity will contribute to the information necessary to help predict relative risk for the ENMs.
Similar(55)
Since there are differences in the systemic potencies of the different ICS [ 18], we also looked at risk by type of ICS.
Given the narrow range of potencies of the different huprines, no strong structure activity relationship trends can be found.
But many comments on the report referred to the lack of peer review, failure to consider major studies, failure to specifically consider the risk of perchlorate exposure to infants, and an excessive reliance on one in vitro study 4 that estimated the relative potencies of the different thyroid stressors in terms of their ability to block iodine uptake.
These approaches also need further evaluation, however; the relative potency of these different molecules must be directly compared, followed by preclinical testing in order to determine how safe and effective they may be in vivo.
Maximal effect (Emax) and half maximal effective concentration (EC50) are commonly measured to compare the signaling efficacies of different ligands as well as potency of the ligands under different conditions.
So the comparison between the potency of different antitoxins obtained by different groups is questionable.
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