To examine the relative potency of these agents, we evaluated the dose dependent effects of these agents upon secreted VEGF and uPA in UMRC2 cells.
In addition, we discovered key differential sensitivities to targeted agents between two-dimensional and three-dimensional cultures, and also demonstrated enhanced potency of some agents against cell migration/invasion compared with proliferation, suggesting their preferential utility in metastatic disease.
N3 N3 dimer 25i displayed striking potency against leukemia, CNS cancer, melanoma and prostate cancer cell lines with GI50 values<0.01 μM against all the cell lines and showed the highest overall potency of the agents examined (GMG=0.0120 μM).
"The very high potency of these agents," he says, "means that [people] become dependent on them very quickly and need to continue to consume to prevent withdrawal".
We next addressed the potency of these agents in reversing hypoxia-exposed gCSC-mediated immunosuppression.
Additionally, hOE-MSCs are an appropriate model for validating the potency of therapeutic agents such as kinetin, a cytokinin that has been shown to increase IKBKAP mRNA and protein expression in FD cell lines and in vivo models [20], [22], [35], [36] as well as in leukocytes of healthy carriers of the FD mutation [37].
Therefore, increasing the potency of chemotherapeutic agents remains a worthy goal.
The potency of carcinogenic agents in eliciting neoplastic lesions has long been a concern of investigators in the field of oncology.
Consequently, by means of inhibition of the P-gp pump, thus reversing cellular resistance, one should be able to restore the inherent potency of antitumour agents.
The potency of the agents is low, but promising results have been obtained in patients with amplified FGFR1 analogous to the treatment of patients with amplified HER2.
