Although emodin's behavior in ERα-transfected SKBR3 cells and BG1Luc4E2 cells was consistent (Table 2), rhodoeosein showed marked cell-specific differences in the potency and magnitude of luciferase induction between BG1Luc4E2 cells and ERα-transfected SKBR3 cells (Table 2).
These findings describe the first known relationship between toxic potency and the magnitude of hormetic response and warrant further inquiry.
Those studies found that TBBPA either did not interact with ERs or that it acted as a weak ER agonist/antagonist with a potency orders of magnitude below that of natural ER ligands.
Using public bioactivity data, we have used MMPs as a consistent reference framework to identify sets of chemical replacements that either have the propensity to induce large-magnitude potency changes or tend to retain compound potency across diverse targets [3, 4].
They are generally easy to make from the parent phenethylamine compounds like 2C-B or 2C-T-2 so in a simple chemical process, you can increase the potency by several magnitudes.
The anxiolytic drug tandospirone is a 5-HT1A recepartialrtiagonistist (60% efficacy) having two to three orders of magnitude less potency for adrenergic, muscarinic, dopamine or any other 5-HT receptors32.
Optimal bivalent reagents exhibited up to 2.5 orders of magnitude increased potency (>100-fold average increases across virus panels) and identified conformational states of virion-bound spikes.
Either decreasing the number of iodine atoms on the molecule to one or increasing the number of iodine atoms to four results in the loss of an order of magnitude in potency.
Compounds 15, 20, 21 and 30 showed considerable activity against the Gram-positive bacteria Staphylococcus aureus while 24 and 30 proved active against Bacillus subtilis with a magnitude of potency comparable to the broad spectrum antibiotic Ciprofloxacin.
3′-Difluorovinyl taxoids exhibit several to 16 times better activity against MCF7, HT-29 and PANC-1 cell lines and up to three orders of magnitude higher potency against NCI/ADR cell line as compared to paclitaxel.
Thus, lipophilicity and antioxidant potency correlated with the magnitude of the beneficial radioprotectant effects observed.
