Sentence examples for potency leads from inspiring English sources

In addition, the reusability of this heterogeneous nanocatalyst is one of its important plus point and also this potency leads us to use it in commercial and industrial applications.

In this way, enhanced inhaled corticosteroid potency leads to greater lipophilicity, slower dissolution and pulmonary absorption of inhaled drug particles with longer retention times in the airways.

The concurrent implementation of a proteome-wide serine hydrolase selectivity screen with traditional efforts to optimize fatty acid amide hydrolase (FAAH) inhibition potency led to the expedited discovery of a new class of exceptionally potent (Ki < 300 pM) and unusually selective (>100-fold selective) inhibitors.

Collectively, these results suggest that ZLA and ZLB may act as dual binding site AChEIs with metal-chelating potency, and may be potential leads of value for further study on disease-modifying treatment of AD.

Overall, this suggests that the bromide substituent at the 5-position does not improve potency and leads to a poorer physicochemical profile.

The next step, therefore, is for chemists to fiddle with the exact arrangement of a promising compound's atoms (subtracting one or two here, adding a few others there, in the way that Hoffmann did when he acetylated salicylic acid) in order to increase its potency.The "lead compound" which results from this tinkering is then subjected to further tests, this time generally in animals.

Structure activity relationships (SARs) study showed that replaced the CF3 in the thienopyridine core could improve the potency and led to the discovery of 8e (IC50 = 16.8 μM) and 9d (IC50 = 12.3 μM) with potent inhibition of hepatic glucose production and good drug-like properties.

Rounds of molecular modeling and inhibitor synthesis to improve stability, selectivity, and potency ultimately led to enhanced binding to the T. cruzi CYP51 target, enabling high-resolution crystal structures to be obtained for this therapeutic target.

Structural complexes of these inhibitors with AfAGM1 and synthesis of derivatives to address solubility, penetration and potency may lead to insights into mode of action and generation of molecules reproducing the genetic phenotype of the agm1 gene knockout.

This systematic analysis of an agonistic antibody interacting with its receptor, in particular the exploration of the relationship between affinity and potency, has led to some surprising conclusions about the nature of agonistic antibody signalling.

VEGF-121 and VEGF-165 have high angiogenic potencies and lead to a rapid and strong invasion of blood vessels.