COX-1 and COX-2 inhibitory potency was evaluated through in vitro cyclooxygenase (COX) assays.
Their potency were evaluated in an enzyme inhibition assay against rabbit muscle glycogen phosphorylase a (RMGPa), a known target protein of oleanolic acid.
A series of trifluoromethyl, benzothiazolyl or thiazolyl ketone-containing peptidic compounds as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays.
New bis-pyridinium oxime reactivators connected with CH2O(CH2)nOCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent.
Haemolysin potency was evaluated using a modified plate assay technique described previously (Quindos et al. 1994).
Gelatinase potency was evaluated using nutrient gelatin differential medium (Oxoid) that tests the ability of an organism to produce an exoenzyme that hydrolyzes gelatin.
In addition potency was evaluated with immunogenicity studies in mice (ED50).
To determine the transdifferentiation activity of the Oct4/ATSC, the neurogenic potency was evaluated through transdifferentiation into a neural lineage.
Paramagnetic potency was evaluated as changes in T1 and T2, the longitudinal and transverse relaxation time constants for MRI.
Although the potency and specificity of Ro3303544 have been evaluated in kinase assays (Adachi et al, 2007), its potency was evaluated in more detail in primary cultures of hippocampal neurons, which are recognized as very sensitive to any toxicity.
