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This judgment about relative toxicological potency is based on the consistent findings of an onset of inflammation at a lower dose (i.e., 50 μg IT) combined with persistence of neutrophilia at 21 days postexposure.
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When Benjamin Franklin, for example, reported in the October 17, 1745, edition of the Pennsylvania Gazette that a medicine made from a substance called "Chinese Stones" could cure rabies, cancer, and a host of other ailments, verification of the medicine's potency was based on personal testimony.
Calculation of LIF-NP potency was based on the release data by 2 days of 300 pg LIF from 1 mg of NP (Fig. 1c) i.e. 3 μg LIF-NP/ml equates to ∼0.9 pg LIF/ml.
The TEF approach is a relative potency paradigm that is based on estimates of the potency of dioxin-like effects of individual chemicals, or a mixture of chemicals assuming a common mechanism of action involving binding of the compound(s) to the aryl hydrocarbon receptor (AhR) (Schmidt and Bradfield 1996).
The potency of this fusion inhibitor is based on its ability to block the conformational change of gp41 and to avert the approach of virus and cell membrane.
In the case of Hyper-IL-6, the high potency of the designer cytokine is based on the fact that the affinity of IL-6 to the IL-6R is in the range of 1 nM whereas the affinity of the complex of IL-6 and IL-6R is 6R is around 10-15 pM, which is about 100 times higher.
Our postulate is based on the speculation that the potency of binding will be increased upon cyclo-aromatization reaction due to increased π-stacking interaction.
One technology that has shown potency in generation of antiviral T cell pools in clinical studies is based on replication-deficient adenoviral vectors.
Oestrogen potency data were based on mouse uterine weight gain and human uterine volume analysis and progestin potency on delay of menses data in humans and the degree of glycogen incorporation in human endometrial vacuoles.
The first is that sample size for potency testing was based on constraints regarding the cost of the chemical assays.
Because exposure was not adequately characterized in the epidemiology studies, the U.S. EPA cancer potency estimates were based on animal bioassay data.
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