A clear trend in increasing potency was found with increasing molecular weight of the polymers examined (at a constant polymer:siRNA (w/w) ratio), with minimal toxicity found.
The results imply that the synergistic effects of amitraz are a promising approach in increasing the potency of certain insecticides in controlling the dengue vector Ae. aegypti mosquito.
Finally, the in situ oral gel may be helpful in increasing the potency of orally administered antibiotics.
Within this series compound 1e combines low nanomolar cytotoxic potency in vitro, increased tumor cell line selectivity, and in vivo activity in a human xenograft model.
On a physiological level, localised drug delivery may result in increased potency at the required site of action while at the same time reducing systemic toxicity [ 18].
In previous work, a mutant G-CSF with weaker receptor binding affinity at the endosomal pH exhibited decreased degradation in vitro through increased recycling of internalized receptor, resulting in increased potency of the molecule in vitro [ 24].
As the drug has gained popularity over the years, so has its potency – increasing in its methamphetamine concentration from 20% to as much as 95% for yaba's more pure, crystalline form, "ice".
All of the four compounds reversibly inhibited the ChEs with their inhibition potency increasing in the same order for both enzymes (1 < 2 < 4 < 3).
