Sentence examples for potency for example from inspiring English sources

We report a soft-drug strategy incorporating a carboxylic ester group into boron-containing PDE4 inhibitors leading to the discovery of a series of benzoxaborole compounds with good potency (for example IC50 = 47 nM of compound 2) and low emetic activity.

Other sources may use a system of color codes to form their own standards of potency; for example, "green", "yellow", and "red".

Conceivably, this process could influence agonist potency, for example, if the affinities of Yn and Yc for each other made a contribution to Y receptor β-arrestin2 binding.

From this initial SAR examination, it was apparent that small structural changes greatly impacted potency; for example, removing the 4-chloro atom from 20 resulted in a ∼10 20-fold ∼10 20-foldency in the unsubstituted pyrimidine, 21.

For example, while use of the other recommended atypical antipsychotics falls within tight dose ranges related to their high potency (for example, risperidone 0.5 to 2.0 mg, olanzapine 5 to 10 mg, aripiprazole 5 to 15 mg), quetiapine, a low potency drug, can be titrated by 25 mg increments from 25 to 300 mg/day [ 6].

In the absence of a good potency assay, for example, it's hard to know how distribution processes are affecting a cell therapy product.

γ-Butyrolactones were developed with varying specificities against Pcaf and a Gcn5-like acetyltransferase, although potencies were modest (for example, the Gcn5 inhibitor has an IC50 of 100 μM) and cellular activity remains to be demonstrated.

In addition, further enhancement of anti-parasite potency can be achieved, for example, by grafting the killing antimicrobial peptides into the antibody CDR loops not involved into the antigen binding [ 43].

Cell growth inhibition studies revealed that compounds 7b– d maintained the inhibitory potencies seen with 7a; for example, 7d inhibited the growth of SW620 and HCT116 cells (GI50 = 0.26 and 0.24 μM, respectively).

But with the rise of China as an alternative mass market, American restrictions on European steel imports or Brazilian citrus, for example, lose potency.

Substitutions with electron donating groups especially at the para position of the phenyl ring enhanced the potency against HIV-1 RT, for example p-methyl substituted compound 5d (52.46 % inhibition) exhibited 1.5 times more potent as compared to un-substituted one (5a) (34.32 % inhibition).