The NCI DTP performed a retrospective analysis of 2306 compounds submitted for NCI60 testing and found a striking correlation between potency and subsequent in vivo activity, which indicates that compounds with high potency are expected to result in good efficacy in later stages of drug development.
EB1089 displayed high potency, as expected.
The ear cleaners Epi Otic® and Otifree® had very little impregnation potency, as expected.
While therapeutic inequivalence of these 4 generics with inferior potency was expected and understandable, in vivo failure of the 5 products that demonstrated pharmaceutical equivalence contradicts current assumptions made by patients, physicians, DRA and the World Health Organization (WHO) [ 13- 17].
Thus, Dr. Decker said, "our impression at this time is that there's no material difference in the expected potency or the effect in use between our product" and the vaccine in the federal stockpile, which was produced in the late 1970's or early 1980's.
The global demand for high potency sweeteners is expected to increase.
Interestingly, racemic MDMA appeared to exert a greater than expected potency and/or an enhanced effect on measures such as movement episodes, center actions (entries and distance), clockwise rotations, and jumps; actions that might be explained by additive or synergistic (i.e. potentiation) effects of the stereoisomers.
As the authors point out, however, the lower than expected potency for 3-methyl-2-butenal is related to hindrance imposed by the bulky disubstituted alkene terminus.
30 The minimum expected potency for the mumps content was higher in the MMRV vaccine (≥104.4 median cell culture infective dose (CCID50)) than in the MMR vaccine (≥103.7 CCID50).
The mRNA vaccine technology is in its infancy, and additional gains in potency can been expected from improved delivery and further optimization of RNA constructs.
