Lazar Chemicals were queried in the tool using the DSSTox carcinogenic potency DBS multicellcall endpoint and the two available mutagenic endpoints (DSSTox carcinogenic potency DBS mutagenicity and Kazius-Bursi Salmonella mutagenicity).
The nonparametric version of the chi-squared test (Fisher exact test) was used for the analysis of the categorical endpoints of potency and 2 dichotomized versions of delta change from baseline EPIC sexual summary score.
The results of the present biomechanical analysis demonstrate that there might be an individual biomechanical solution for each non union such that, given local biological potency is intact, the endpoint of full circumferential fusion is not mandatory.
For continuous drug exposure and suppression of population growth as the endpoint, the potency of Ro 31-1741 wasimilarar to that of ADM, whereas that of Ro 31-1215 was 1.5-2 x higher and that of Ro 31-2035 was 10-20 x lower.
The fact that potency comparison is across different endpoints and model structures is not a limitation given that the main interest is in comparing LY2878735 to duloxetine.
For the quantitative data from laboratory 9, no potency could be estimated by endpoint evaluation because only 1 dilution was tested for each sample.
The antiviral potency of A38 was measured by an endpoint dilution (5 μM, 2.5 μM, 250 nM, 25 nM, 2.5 nM, 250 pM) and immuno-fluorescence-based assay in Hep2 cells against VACV (Fig. 4), followed by determining the ratio of infected/non-infected cells.
The efficacy and potency parameters obtained for the four modelled pharmacodynamic endpoints are presented in Table 3.
It is therefore important to agree on the endpoints to consider as metrics of "potency" and recognize that as new science becomes available our perception of the relative potency of chemicals may change.
