Sentence examples for potency depending on from inspiring English sources

Marijuana varies in potency, depending on the variety and where and how it is grown, prepared for use, and stored.

Amide-type pipecoloxylidide local anesthetics, bupivacaine, and ropivacaine, show cardiotoxic effects with the potency depending on stereostructures.

Kinase profiling showed that the imidazo[1,2-a]pyrazines could inhibit other kinases, including CHK2 and ABL, with equivalent or better potency depending on the pendant substitution.

Indeed MF binds GR-α with mostly antagonistic activity; yet it may have agonistic potency depending on the concentration of GR in the cell [ 48].

Additionally, conjugation of 36 to polyamidoamine (PAMAM) dendrimers yielded agonists with enhanced potency, depending on the density of pharmacophore substitution of the polymer.

The bis-pyridinium oximes showed stronger activity compared with mono-pyridinium oxime, and the magnitude of reactivation potency depended on the length of the methylene linker.

The potency depends on the number of galactose moieties attached to the oligomer backbone and the length of the linker tethering these carbohydrates.

Finally, to investigate whether the decreased presynaptic function resulted in reduced glutamate levels at the synapse we used γ-d-glutamylglycine (γ-DGG), a low-affinity competitive antagonist of the AMPARs, at a non-saturating concentration (0.5 mM) at which its potency depends on glutamate level26.

(E) The low-affinity competitive antagonist γ-d-glutamylglycine (γ-DGG), at a non-saturating concentration (0.5 mM) at which its potency depends on glutamate concentration decreased neurotransmission to a greater extent in CD and KD fed mice compared to SD controls (SD, n = 9; KD, n = 6, p < 0.001; CD, n = 7, p < 0.05), indicating lower glutamate synaptic concentrations in the KD and CD groups.

Biochemical potency depends on receptors that have been designed by evolution to be sensitive to subtle changes in chemical structure (for example estrogen vs. testosterone, or epinephrine vs. norepinephrine) whereas the hERG channel has been designed to transport potassium and has had little or no evolutionary pressure to be selective against micromolar concentrations of aromatic amines.

Being a substrate of the efflux transporter, verapamil may cause competitive inhibition of the transporter function and, therefore, its inhibitory potency depends on the degree of interference with another substrate (in our case rhodamine B) when both bind to the substrate binding site of the protein.