Muscle potency, determined by using the startle assay showed no differences between groups (Fig. 1E).
Although we attempted to explore uncertainty in cancer potency factors by using OEHHA and U.S. EPA values, actual uncertainty in these values greatly exceeds the differences in the values used by these agencies.
This result suggests a strategy for increasing inhibitor potency by use of a second-generation combinatorial library designed to give simultaneous occupancy of both binding sites.
Then, we predicted a set of high-potency natural products by using the iPPI-likeness score based on a docking score-weighted model.
For qualitative assays, relative potencies were determined by using parallel-line analysis of probit-transformed data.
Estimation of endpoint dilution and relative potencies was performed by using CombiStats version 4.0 (European Directorate for the Quality of Medicines and HealthCare/Council of Europe, Strasbourg, France).
The compounds screened after pharmacophore-based search were further evaluated for their inhibitory potency against Cathepsin L by using Schrodinger's Glide docking platform [ 49, 50].
Kendrick not only supplied the British with American serum to compare with the British vaccines and assisted in designing their study but also, with MRC funding, tested the potency of the vaccines, by using a mouse protection assay developed in the Grand Rapids laboratory, before the vaccines were used in the MRC field trials (13, 35 ).
Antagonist potency values (pKB) were determined by using the operational model for apparent non surmountable compounds, or by applying Schild's analysis for compounds displaying surmountable profiles [41], [42].
By using cancer potency factors, our estimates likely represent upper-bound risks, but the internal consistency of our methodology allows us to compare among compounds and with other published studies.
