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Although the study indicates that OTA is associated with deletion mutations in the target tissue, the potency of effect was low, especially in relation to effects reported in this assay for known genotoxic chemicals such as N-nitrosopyrrolidine and amino-3-methylimidazo[4,5-f]quinoline (Kanki et al., 2005) and in relation to the potency at which OTA induces kidney tumors in rats at very low doses.
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Although overexpression of mutants has been used to explore the role of dynamin, even mutations that effectively target the dynamin GTPase, such as dynamin K44A, S45N, T65F and T65A, vary in their potency and the stage at which they inhibit endocytosis [ 8, 20].
Total activity potency (TAP) is the volume at which the components, extracted from 1 g of material, are diluted enough to maintain the same potency against the test pathogens.
He understood the potency of this popular medium at which he excelled.
For body waves, the effect of seismic potency at shallow depth, which increases amplitudes, may be smaller than the effect of the source radiation pattern, which decreases amplitudes for shallow subsources.
The pathways identified will help in the design of novel conotoxins with increased potency at α4β2, for which there is currently no known highly potent conotoxin inhibitor.
This was probably a consequence of their lower potency and the inability to reach concentrations at which a Gs response would be visible.
This assay assesses the potency of antibiotics by determining the minimal concentration at which no visible bacterial growth can be observed.
Although toxicity increases with increasing tag length, compositions could be found at which little or no toxicity is observed, but where the peptides display high bactericidal potency.
The location at which the belt interacts with a GPCR determines the conformation and functional status of the latter, including ligand potency and efficacy.
And at which port?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com