Sentence examples for potency and specificity of from inspiring English sources

We demonstrated the potency and specificity of these peptides as Mcl-1-specific reagents in BH3 profiling assays.

In addition, medicinal chemistry will be used to improve potency and specificity of RAD288 and RAD289.

However, improvement of the potency and specificity of such therapeutics remains a major challenge.

Contemporary medicinal chemistry faces diverse challenges from several directions, including the need for both potency and specificity of any therapeutic agent.

The inhibitory data against the RTKs in this study demonstrate that variation of the 6-ethylaryl substituents as well as the N4-phenyl substituents of these analogs does indeed control both the potency and specificity of inhibitory activity against RTKs.

The aim of the present study was to compare the efficacy, potency and specificity of two GRF analogues with those of the native GRF(1 29 NH2using pig (p) as the animal model.

Peptides are emerging as a new class of therapeutics due to their high potency and specificity for a range of targets, including the inhibition of protein protein interactions.

Such a combined application of Y16 and rhosin provides added potency and specificity for the inhibition of RhoA activation in cells.

It was selected as a promising antifungal AMP because of its potency and specificity to inhibit the growth of filamentous fungi.

Importantly, although these studies are focused on a lead small molecular compound, NSC-124854, it provides insight into the rational development of second generation small molecular compounds with greater potency and specificity for the treatment of colon cancer.

In comparison with first and second-generation of P-gp inhibitors, third-generation inhibitors such as pyronaridine (PND) have advantages, such as higher potency and specificity for P-gp, lack of non-specific cytotoxicity, relatively long duration of action with reversibility, and good oral bioavailability.