The different potencies and multiple modes of action on nAChRs may help to better understand the pharmacology of these receptors and to aid in novel drug design.
A high barrier to entecavir-resistance (ETVr) is observed clinically, likely due to its potency and a requirement for multiple resistance changes to overcome suppression.
Potent synthetic steroids are examples where only slight structural modifications relative to their endogenous analogs can induce drastically higher potency and enable interactions with multiple receptors, including responses not intuitively obvious from structural inspection alone.
They are known to regulate basic developmental processes such as cell fate determination and cellular potency in multiple stem-cell types, including the sensory nerve cell progenitors of ganglia in mammals.
The star topology reflects the presence of a highly or lowly potent compound and multiple analogs having opposite potency, a situation frequently observed in compound optimization.
The comparative analysis suggests that the existences of dodecahydroisoquinoline ring at P1′ subsite, 4-aminophenylsulfonamide at P2′ subsite, and bis-tetrahydrofuranylurethane at P2 subsite are helpful for maintaining the high affinity of the inhibitor for the protease and exhibiting high potency against multiple drug resistance (MDR) mutant protease.
It was observed that kanamycins have nonspecific and multiple interactions with RNA hairpins and that the binding potency is not always proportional to the antimicrobial activity.
Yet the clinical development of therapies targeting the FGFR signalling pathway presents multiple challenges, with diverse mechanisms of pathway activation combined with multiple inhibitors of differing potency and with antibodies in preclinical development.
The atypically inordinate degree of post-laser inflammation and multiple sequelae following encircling retinopexy/cerclage as retinal detachment prophylaxis, in this case, demonstrate the potency and risks of retinal photocoagulation.
He had multiple marriages and multiple divorces.
