Exact(9)
This study was designed to evaluate the effect of homeopathic preparation of Cephalendra indica (family Cucurbitaceae) mother tincture (MT), 6 C and 30 C potencies on DN in wistar rats.
"Agmatine analogs", MR-356 (N-Me-Tyr1-JI-38), MR-361 N-Me-Tyr1, D-Ala2-JI-38) and MR-361 N-Me-Tyr1, D-Ala2, Asn8-JI-38), in which Dat in JI-38 is replaced by N-MR-361 N-Me-Tyr1iMR-361 N-Me-Tyr1 potencies on GH release upon subcutaneous administration in vivo and binding in vitro.
Our data show that CM and cocaine have very different potencies on the major cocaine targets, and therefore, equimolar systemic doses of CM do not produce equivalent inhibition of major cocaine targets.
Since CM is primarily used to identify cocaine effects in the periphery, where sodium channels are potential targets, we sought to determine whether CM and cocaine had similar potencies on sodium channels in peripheral nerves.
Both compounds exhibited different potencies on glucose transport, and GAG and HA synthesis.
However, there was little correlation between potencies on PTR1 or DHFR-TS and activity in the whole cell assay.
Similar(51)
The corresponding 2,6-substituted pyridine 27 sustained the potency on hSUCNR1 and almost regained the potency on mSUCNR1.
Therapeutic selectivity, however, depends on the difference between potency on disease-causing cells and potency on non-target cell types that cause toxic side effects.
The elongated trifluoroethoxy analogue 32 showed improved potency on the mouse orthologue.
Replacing the furane of 3 with the 1,3-substituted phenyl 25 improved the potency somewhat on the human orthologue whereas the potency on the mouse orthologue decreased 10-fold.
Compound 17 is a novel lead with low picomolar potency on all three Pim kinase isoforms.
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