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Compound 14 exhibited low nanomolar KDR enzymatic and cellular potencies (IC50 = 9 and 52 nM, respectively).
Urotensin-II contracted cat isolated trachea and bronchi with similar potencies (pEC50s 8.61 ± 0.07 8.81 ± 0.10).
Additionally, M. oleifera leaves also showed significant anti-inflammatory [64], and antioxidant potencies [63], [65], which may be contributing to its hepatoprotective activity.
Antagonist potencies (pA2) in the rat ranged from 5.52 to 9.56 and correlated with the human binding affinities (r2=0.86).
The nature of their side chains gave rise to a variety of possible structures and stereochemistry determining their different potencies [1] [4].
Clozapine antagonised 5-HT-activated currents through human and murine 5-HT3 receptors with different potencies [5], [24].
Cocaine also blocks sodium channels but with lower potencies (50 µM or higher) [5].
The inhibitory potencies (IC50 values) of Af23 and Ad23 were much greater when compared to NDGA.
NRTI-free regimen such as PI monotherapy are not recommended because of inferior antiviral potency [ 17, 18, 21- 23].
Ordinary chemical assays and light microscopy cannot detect the nanoparticles, especially at higher potencies [ 84, 85].
Balancing selection might be maintaining many maxadilan alleles with equivalent vasodilatory potencies [ 25, 26].
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