Sentence examples for postulated to generate from inspiring English sources

Hyperglycaemia has been postulated to generate oxidative stress via several well-studied, interconnected pathways which ultimately lead to nerve dysfunction essentially by the activation of downstream signaling pathways involving NF- κB, mitogen activated protein kinases (MAPK), proinflammatory cytokines, and gene transcriptions [ 11].

In this study, the alternatively spliced TPO transcript with an insertion of 34 bp between exon 12 and exon 13 is postulated to be generated as a result of the interruption of the ESE-binding site sequence in exon 13 of the TPO gene and has abolished the binding motif of three SR proteins, SRp40, SF2/ASF, and SRp55, which are required to strengthen the use of the wild-type (WT) splice site.

On the other hand, alterations in intracellular calcium homeostasis are postulated to participate in the mechanisms generating potentially lethal plasma membrane injury.

The dAdo radical produced by reductive cleavage of SAM is postulated to abstract a hydrogen atom from the substrate to generate a radical intermediate.

In the CIF-iPLA2 model of SOCE, the lysoPLs generated by iPLA2 are postulated to activate store-operated channels directly.

The virus itself has been postulated to induce thyroid auto-antibodies by ways of generating high endogenous IFN levels triggering off autoimmune thyroid disease in susceptible individuals, similar to Coxsackievirus.

Underlying mechanisms are postulated to include ischaemic hypothalamic damage and the inability of hypoxic mitochondria to generate heat.

After oxygen binding, the resulting ferric superoxo species is postulated to abstract the pro- S hydrogen atom from C2 of 2-HEP to generate a substrate radical as shown in Scheme 5.

Plasmodesmatal myosin VIII was postulated to be involved in regulating conductivity by the force it can generate to control the spacing between desmotubules and plasma membrane [ 11].

The incorporation of newly generated neurons in the DG has been postulated to increase the cell number and volume of the DG during the first 8 months of age [56], [57].

Dentate maldevelopment has been postulated to be an abnormal tissue focus that triggers seizures or generates cardiorespiratory instability (independent of seizures).