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Inadequate blood volumes, early patching, steroids in the epidural space and dural punctures performed with large bore needles were postulated to be possible causes of EBP failure [27, 110].
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Two crosslinks along the PEDLDRERREHDREER peptide position it directly along the basic groove that abuts the active site of CKIε, which was postulated to be a possible phosphate recognition region [50], [55] [60] (Fig. 8B).
These cuttings are postulated to be among the possible causes of many costly complications, such as mechanical pipe sticking, bore hole instability, drag and torque.
In fact, one possible mechanism postulated to be responsible for QD cytotoxicity is free radical formation, particularly reactive oxygen species (Clarke et al. 2006; Hoet et al. 2004; Oberdörster et al. 2005), during the synthesis and application of QDs.
In order for this to be possible one must postulate that tolerance breakdown and the selection of a pathogenic repertoire is the result of environmental hits on a stochastically generated B cell repertoire in a genetically predisposed individual.
We propose that rather than dedifferentiation of SSCs as earlier postulated, it may be possible that the VSELs per se expand to give rise to ES-like colonies in vitro [ 20].
To overcome the resistance of glioblastoma cells to TMZ, it has been postulated that it is possible to combine TMZ with other drugs to enhance glioblastoma cell response to TMZ cytotoxicity.
We postulated that it might be possible to design age-adjusted treatment modalities based on the mechanisms responsible for the reduced tumour progression rate in the aged.
It was therefore postulated that it might be possible to intervene in this subgroup of CF patients by using drugs that potentiate the existing CFTR function.
It was postulated that it may be possible to mimic the action of CC without depletion of estrogen receptors by administration of an AI in the early part of the menstrual cycle.
While plausible mechanisms for how a pacifier may contribute to the early cessation of breastfeeding have been postulated it is possible that the use of a pacifier may simply be a marker of breastfeeding problems that result in the early cessation of breastfeeding rather than an independent cause of breastfeeding cessation [ 10].
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