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To date, two focal adhesion proteins, talin and p130Cas, have been postulated to act as putative mechanosensors, acting through mechano-induced unfolding of their particular soft domain(s) susceptible to phosphorylation.
However, in the past years, exercise has been postulated to act like a drug [2] and, as such, provides advantages and risks to an individual's health and fitness.
Dendritic cells bind an array of antigens and DC-SIGN has been postulated to act as a receptor for mucosal pathogen transmission.
The presence of multiple genes at sites of transcription (transcription factories) has been postulated to act as a stabilising force on chromosome architecture [39] and inhibition of transcription can cause some retraction of chromatin loops [40].
Secreted mucin with the Sia-α2-3 receptor has been postulated to act as binding-decoy for influenza H5N1 virus, reducing the possibility of the virus to bind to the bronchial epithelium and achieve productive replication in the airway.
Studies suggest that up to 80% of NPY-expressing neurons in the Arc are co-localized with Y2 receptors, and Y2 receptors have therefore been postulated to act as auto-receptors that modulate the synthesis and release of NPY [7], [28], in keeping with the effects of Y2 agonists on NPY release from hypothalamic explants in vitro [25].
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It is known that the receptors of AngII are expressed in culture osteoclasts and osteoblasts, and AngII is postulated to be able to act upon the cells involved in bone metabolism [ 22].
Therefore an additional role of TRP channels may, as previously postulated, be to act as scaffolding proteins (reviewed in [ 46]).
The environmental factors are postulated to be compounds that act as endocrine disruptors; they affect the developing testes and lead to male reproductive tract anomalies by altering the balance of androgen and estrogen action.
For instance, conscious acts are just postulated to be interpretable somehow analogously to physical acts of measurement, or correlations in psychological systems are just postulated to be interpretable somehow analogously to physical entanglement.
The ideas postulated here are envisaged to act as a starting-point for future R&D direction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com