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Its existence had been postulated since the late 19th century, and astronomers working under Percival Lowell, the observatory's founder, had been chasing it photographically since 1906.
A pathological role of these autoantibodies has been postulated since they can inhibit the enzymatic activity of GAD65 in vitro [15], [16].
Furthermore, a tissue-specific role for SmTK3 was postulated since localization experiments identified expression products in the gonads of S. mansoni males or females.
A role for PDGF-bb in bone formation has been postulated since recombinant PDGF-bb, as other PDGF isoforms or BMP-2 and BMP-4 isoforms, has been shown to be a powerful chemoattractant for mesenchymal stromal cells and osteoblasts in vitro [21].
Neuronal elements that gate the activation of lower-level procedures are known or postulated since long.
Several hypotheses are postulated since long days to address these questions.
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Enkephalins and closely related substances known as beta-endorphins were discovered when investigators postulated that since exogenous (produced outside of the human body) opiate substances such as morphine bind to cell surface receptors, there must exist endogenous (produced inside the human body) opiate-like substances that do likewise and therefore have a narcotic action.
The authors postulated that since the study used a migraine-specific measure, it might not have been able to truly capture the essential aspects of CH [7].
The authors postulated that, since in wild-type strains the psaA mRNA is spliced in trans from three separate precursors, the precursor psaA-exon1 would over-accumulate in mutants defective in psaA transsplicing.
He then postulated that since the "problem" was made up anyway, that any Unilever product, including his own "Stephen Colbert's Americone Dream" ice cream (Ben & Jerry's is a wholly-owned subsidiary of Unilever), could treat those unsightly lady pits.
It may be postulated that since impairments of the immune responses for S.pneumoniae are even seen for young infected patients, these findings have considerable value for patients with underlying diseases predisposing to pneumococcal infections.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com