Our study confirms the known or postulated role of many of these in prostate pathology, and identifies additional genes that appear worthy of further investigation.
In addition, the previously postulated role of heterozygous LIMK1 deletion in the spatial cognition phenotype of WBS individuals was refuted in more recent studies (Gray et al, 2006).
Preliminary studies have indicated that mice lacking the gene encoding calcitonin and CGRP-α lose more than twice as much skeletal calcium content as their wild-type sisters during three weeks of lactation [ 21], confirming a previously postulated role that calcitonin might protect the maternal skeleton from excessive resorption during lactation.
These gene expression data are further supported by immunohistochemical localization of the Leydig cell maturation marker INSL3, which is present in all Leydig cells of control testes but is restricted to a subset of Leydig cells within LCARKO testes (Fig. 4 G ). Together, these data strongly support the previously postulated role for Leydig cell AR in promoting adult Leydig cell maturation.
However, Hogenboom et al. (2004) found a cytosolic localization of endogenous human MK using immunofluorescence microscopy and immunocytochemistry, the postulated role of peroxisomes in isoprenoid biosynthesis has been challenged (Hogenboom et al. 2004).
Another example is the postulated role of homocysteine in atherosclerosis.
The current postulated role of gastrokine-1 in mucosal protection was deduced from its cellular localisation in the gastric epithelium.
Increased actin polymerization near the plasma membrane, which is associated with increased macropinocytic uptake, may explain the postulated role of Rac1 in regulation of macropinocytosis.
These findings are in line with the postulated role of CK1 family members in regulating vesicle budding and transport processes [1], [2], [19], [56], [57].
The strict correlation of BORIS expression with aberrant expression of multiple growth-promoting proto-oncogenes in a variety of solid tumors reinforces the postulated role for BORIS as a key participant in aberrant demethylation and transcriptional activation of putative oncogenes.
tesA, encoding a type II thioesterase, is located immediately upstream of a large virulence cluster involved in pDIM biosynthesis and has a postulated role in the release of mature lipids from the pDIM synthesis machinery [42], [45].
