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For each postulated position, the method only requires information from the two flanking markers.
Apoptosis persists upon regression of the placode, thereby exhibiting a massive "wedge" of apoptotic cells which includes the postulated position of the "ventrolateral postoptic placode" (Lee et al. in Dev Biol 263:176–190, 2003), merges with groups of lens-associated apoptotic cells, and disappears upon lens detachment.
Hence, the wedge of apoptotic cells somehow reflects the postulated position of the ventrolateral postoptic placode (Lee et al. 2003).
They computed the likelihood function (4) using – at each postulated position of the disease locus – the information from the two flanking markers.
In T. belangeri, spatiotemporally regulated patterns of apoptosis and proliferation were found in non-delaminating rostralmost parts of the placodal field, in the postulated position of the ventrolateral postoptic placode, and in the mature trigeminal placode.
Other parts of the placodal field which, in T. belangeri, were additionally found lateral to the forebrain and/or lateral to the rostral midbrain appear to confirm the reported rostral extension of the ophthalmic trigeminal placode (McCabe et al. 2009) and, possibly, include the postulated position of the ventrolateral postoptic placode (Lee et al. 2003).
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The first was begun by Danish astronomer Hans Emil Lau who, after studying the data on the orbit of Uranus from 1690 to 1895, concluded that one trans-Neptunian planet alone could not account for the discrepancies in its orbit, and postulated the position of two planets he believed were responsible.
In the first two libraries, we addressed positions postulated as important specificity determinants [25], [26], [27].
At least partly inspired by the successful examples of the "shared epitope hypothesis" for pathogenesis of rheumatoid arthritis or type 1 diabetes mellitus [36], [42], [43], it has been postulated that arginine at position 74 of the HLA-DRB1 chain is critical for GD pathogenesis [44], mostly based on the association findings from studies conducted in Caucasians.
It would seem logical, therefore, to postulate that positive histone marks are positioned according to a code determined by the sequence-specific TFs.
Summarizing the main conclusions from literature review regarding the CTO position, it can be postulated that on the one hand, this position can be characterized as an actively spreading function in the contemporary business.
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