The reasoning behind this assumption is that cells treated with RNAi to BAZ1B showed an increase in HP1β, which was postulated to represent gain of heterochromatin [ 18], and that HP1 is a feature of centromeric heterochromatin [ 59].
Based on the principle of parsimony, and looking at the 16S tree (Fig. 2A), one can postulate four gains to explain these nine additional A homologues (Fig. 2): one in the common ancestor of M. smegmatis, Mycobacterium JLS, Mycobacterium KMS, Mycobacterium MCS and M. vanbaaleni; one in the common ancestor of N. farcinica and Rhodococcus RHA1; one M. smegmatis and another in Nocardioides.
Regarding prognostic impact, detection of 2p gains increased up to 28% of patients in untreated Binet B/C patients and it has been postulated that 2p gains are a secondary event associated with a shorter OS and an increased risk of transformation to Richter syndrome [ 106, 107].
As the hierarchical structure of the case study is typical for many batch scheduling problems, some general principles may be postulated from the experience gained here.
We postulated that, if dsDNA gains access to these endosomes by BCR-mediated entry, the difference in potencies between double-stranded and single-stranded versions of the same inhibitory sequence would disappear.
From this finding, we postulate that weight gain related to paroxetine occurs mainly during the first 12 months of treatment.
Namekawa and colleagues [ 54] demonstrated the presence of these cells in the synovial tissue of patients with RA, again postulating that the gain in cytotoxic function is of functional importance in maintaining chronic synovitis.
The G2019S mutation occurs within a highly conserved activation segment of the protein and is postulated to result in a gain of function of its kinase activity, compatible with its autosomal dominant mode of transmission [23], [24].
The developmental and morphological variety of subsection V cyanobacteria places them among the most complex of prokaryotes, for which reason they were even long thought to be the direct ancestors of all eukaryotes but only in the days before the endosymbiotic origin of plastids has been postulated (Mereschkowsky 1905) and eventually gained compelling support (Doolittle 1980).
Increased central gain has also been postulated as one of the possible mechanisms of tinnitus generation [ 17, 18].
