Sentence examples for postulated disruption from inspiring English sources

The study referenced by Shamash et al (2008) did not utilise taxanes (that through their postulated disruption of AR signalling may be associated with cross-resistance with endocrine treatments) and allowed cessation of androgen deprivation with 49% of patients having non-castrate levels of testosterone at the completion of chemotherapy (Shamash et al, 2008).

Jain et al. postulated that disruption of cytokinin flux to detached leaves triggers the selective degradation of carbonylated proteins via autophagy.

It has been postulated that disruption of both PML and PRH functions by the PML RARα fusion protein might well contribute to leukaemogenesis in APL [ 19], but this has yet to be demonstrated directly.

Neuromyotonia is often associated with autoantibodies against potassium channels [ 7], and it has been postulated that disruption of K+ channels is a key element in the production of neuromyotonia.

The genetic regulatory network that leads to the formation of the Isthmic Organizer is highly conserved across vertebrates, and beyond (Robertshaw and Kiecker, 2012), and it has long been postulated that disruption of the Isthmic Organizer must, therefore, be a cause of human cerebellar malformation.

It was then postulated that disruptions to the blood-retinal barrier secondary to retinal ischemia in susceptible patients could result in macular crystal formation in WACM, likely as a result of exudation of pre-formed crystals or precipitation from exudated serum [3].

The vascular hypothesis of Alzheimer's disease postulates that disruption of the brain microvasculature is important for the accumulation of amyloid beta and increased neuroinflammation.

They postulate that disruption of even a single water bridge interaction (e.g., acetylation of H3K64) has the potential to significantly affect nucleosome stability.

Instead, we postulate that disruption of the hydrophobic core caused by the Trp8 mutation misaligns the carbonyl oscillators in the three sheets causing the decrease in splitting and intensity.

The first mechanism of toxicity postulated is membrane disruption and subsequent disturbance of intracellular homeostasis.

Since the targeted mutation of PML increases the yield of infectious viral particles [26], it is postulated that the disruption of PML NBs and the re-localization of PML protein represents a viral strategy to evade a cellular resistance mechanism.