Each treatment firm can also be closely matched to a control firm, and exploiting each inclusion firm's behavior pre and post inclusion relative to the matched control firm results in a difference-in-difference (D-in-D) regression setting that eliminates time varying effects common to both firms, any inclusion effect common to all inclusion firms, and all firm fixed effects.
Regular trial participation for each patient terminates 2 years post inclusion into the trial or the patient's death respectively.
See Table 3 for comparisons between the two groups with regards to days spent in hospital (DIH) and number of admissions pre-and-post inclusion.
The outcome of interest is the probability of remission achievement (rate of remission) of the index episode at 15 months post inclusion.
First, our observations for the detection of diarrhea were limited to seven days post inclusion, while first signs and symptoms might have occurred later on.
IPS will be compared to high quality treatment as usual (TAU), with labor market participation and educational activity at 12 months post inclusion as the primary outcome.
We will also assess the response rate and relapse at 15 months post-inclusion, hospitalization rate and adherence to treatment during the follow-up period, quality of life and global functioning upon inclusion and at 9 and 15 months post inclusion.
It will consist in the number of missed sessions, and satisfaction at 3 months post inclusion using a Likert scale ranging from 0 (not useful at all) to 10 (extremely useful) for the intervention group.
The between-group comparison on variation in treatment adherence using MARS and changes in benzodiazepines doses between inclusion and 15 months post inclusion will be performed using the student-t test if distribution is normal or the Mann–Whitney test, if otherwise.
It relies on assessment of suicidality using the Columbia Suicide Severity Rating Scale (C-SSRS) [ 59]: rate of suicidal behaviors (completed suicide and suicide attempts) at 15 months post inclusion, variation of severity and intensity of suicidal ideations subscores between baseline and at 3, 6, 9 and 15 months after inclusion.
