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The first successful screens for genes that postponed aging began in the mid 1980's.
Thus it was proposed that progress in finding the right genomic and physiological information for postponing human aging required the development of mice with selectively postponed aging [ 34].
Thus it is easy for evolutionary biologists to deliberately produce organisms with slowed or postponed aging, as our publications have shown since 1980 [ 1, 4].
Thus evolutionary biologists expect that experimental manipulations which attenuate reproduction will often increase longevity, but because this involves trading one adaptation for another, we do not regard the resulting demography as a case of slowed or postponed aging.
In conclusion, the progress of medicine 60-100 yeago ago (in prevention and treatment of non-age-related diseases) allowed slow-aging individuals to survive long enough to die from late onset age-related diseases (in other words to die from postponed aging).
Similar(55)
That observation set Bartke and two postdocs, Holly Brown-Borg and her husband Kurt Borg, wondering: If having too much growth hormone could make an animal age faster, perhaps having no growth hormone would postpone aging.
Then there was no natural selection to postpone aging.
However, it is has remained unclear whether increased glyoxalase I levels only serve to protect normal growth and survival under adverse conditions, or whether they are able to postpone aging and increase health at advanced age, as a means to longevity.
Similarly, addition of resveratrol postponed age-related decreases in locomotor activity of short-lived vertebrate fish, N. furzeri [ 18].
First, IGF-1R deletion slowed down proliferation in actively dividing progenitors, possibly increased stem cell self-renewal, and eventually postponed age-related attrition of the neuroblast compartment.
Here we showed that chronic treatment of female outbred SHR mice with metformin started at the age of 3, 9 or 15 months decreased body temperature and postponed age-related switch-off of estrous function.
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